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Beilstein J. Org. Chem. 2018, 14, 875–883, doi:10.3762/bjoc.14.74
Graphical Abstract
Scheme 1: Previously reported post-Ugi-4CR methods for the synthesis of 2-oxindoles and spirocyclic 2-oxindol...
Scheme 2: Post-Ugi-4CR/transamidation/cyclization sequence.
Scheme 3: Base-promoted intramolecular 5-endo-dig cyclization.
Figure 1: ORTEP diagram of compound 7a.
Figure 2: Readily and synthetically accessible starting materials.
Scheme 4: Reaction scope with varying combinations of substrates.
Scheme 5: Synthesis of 5-chloro-1'-phenylspiro[indoline-3,2'-pyrrolidine]-2,5'-dione (8a).
Figure 3: Small molecule library of spiro[indoline-3,2'-pyrrolidine]-2,5'-dione analogs.
Scheme 6: Method applicability for the one-pot synthesis of 5-HT6 receptor antagonist 8j [53].